G8648
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G8648
Sigma-Aldrich
Gentamicin sulfate salt
powder
| CAS Number: | 1405-41-0 |
| EC Number: | 215-778-9 |
| MDL number: | MFCD00270181 |
Description
| Application | Recommended for use in molecular biology applications at 10-15 μg/ml. |
| Biochem/physiol Actions | Mode of action: Gentamicin causes codon misreading by binding to the 30S ribosomal subunit, blocking the translocation of peptidyl-tRNA from the acceptor site to the donor site.1,2 The bactericidal effect of gentamicin on Pseudomonas aeruginosa is exerted by the binding of gentamicin to the outer membrane, where it displaces natural cations, destabilizes the membrane, and forms holes in the cell surface.3 Antimicrobial spectrum: Gram-negative bacteria, Staphylococcus aureus and other Gram-positive bacteria |
| Reconstitution | Prepare stock solutions directly in the vial with sterile water (5-20 mg/ml). Stock solutions should be stored at −20°C. Stable at 37°C for 5 days. |
Properties
| sterility | γ-irradiated |
| form | powder |
| storage temp. | 2-8°C |
Safety
| Personal Protective Equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
| Hazard Codes | Xn |
| Risk Statements | 42/43 |
| Safety Statements | 22-36/37-45 |
| WGK Germany | 2 |
| RTECS | LY2625000 |
References
| Cited Reference | 1. Korzybski, T., et al. Antibiotics: origin, nature, and properties Washington, DC , (1977), 712-723 |
| 2. Lorian, V. (ed.) Antibiotics in Laboratory Medicine 2nd ed., Baltimore, MD , (1986), 694-696 | |
| 3. Kadurugamuwa, J., et al., Surface action of gentamicin on Pseudomonas aeruginosa J. Bacteriol. 175, 5798-5805, (1993) |
